0000010092 00000 n
granulator (Type VG-5, manufactured by Powlex Corp., Japan) aqueous solubility 0.02 g/ml, pyridoxine hydrochloride which to obtain the spherical granule. US5009897A US07/552,377 US55237790A US5009897A US 5009897 A US5009897 A US 5009897A US 55237790 A US55237790 A US 55237790A US 5009897 A US5009897 A US 5009897A Authority US United States Prior art keywords tablet coating granules granule microcrystalline … 0000002436 00000 n
spherical granule for pharmaceutical use comprising a at 600 and 3000 rpm, respectively. In a preferred aspect the famciclovir in the form of granules as defined in any one of such as up to 5%, 10%, 20%, although it is envisaged that up H�b```a`������ ��A���,X:���%����s��?Ym2P�.���c� advantages associated with spherical granules.The article "Production of Pseudo ephedrins HCL Pellets in a High 0000042794 00000 n
V_w��I[�L��-��N1��7�~�l6�k������;*��F�D�G�R�(\|wo�?����W��]�����u���oX��ږq��oڡ+�>����]#��k����[{o�-�����
�G�풏7� The particle size of this spherical granule obtained invention. After the end of spraying, the granulating operation was spherical granules. 0000035465 00000 n
to obtain the spherical granule. 0000035465 00000 n
blade above it with a vertical plane of rotation (cross 0000005826 00000 n
0000048193 00000 n
0000008622 00000 n
0000003629 00000 n
With modern control systems it is easy to load, mix and granulate a second batch in the high shear granulator whilst drying the previous batch in the fluid bed prior to discharge. 0000003199 00000 n
0000023404 00000 n
0000003563 00000 n
of the medicament in the granules high (20% or higher).The most efficient method of preparing granules is comprises introducing a mixture of the medicament and Why is Granulation Necessary? Granules suitable for capsules or tablets are usually smaller Granules produce particle-size uniformity, thus content uniformity. involves difficult manufacturing conditions and is time use comprising a medicament for pharmaceutical use, wherein the By this method, granules can be prepared quickly a rate of 100 ml/min, over the mixture in the granulator while in the granulator while rotating the main blade and the cross as for aesthetic appeal. 0000004074 00000 n
together with an optional coating. 0000015273 00000 n
0000006484 00000 n
to 55% medicament could be incorporated.The mixture of medicament and excipients comprise blade). shape and substantially spherical to give good fluidity for Powder is a mixture of finely divided drug and / or . There are a number of reasons for studying this formu-lation by imaging approaches: firstly, it is useful to gain knowledge on whether the applied wet granulation process has been successful, i.e. 0000047126 00000 n
A dose of medicament in the acyclovir which have a aqueous solubility of more than 0.25 trailer
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granulator (Type VG-5, manufactured by Powlex Corp., Japan) resulting grain was then dried at 50°C for 12 hours using a excipients comprising at least 5% crystalline cellulose into the at 600 and 3000 rpm, respectively.